Na Nọvemba 9, 2021, ụdị dị iche ichecoronavirus ọhụrụAchọpụtara B.1.1.529 na nke mbụ site na nlele nke ikpe South Africa.N'ime ihe na-erughị izu abụọ, ụdị mutant a ghọrọ nnukwu ụdị mutant nke ọrịa ọrịa okpueze ọhụrụ South Africa, na uto ngwa ngwa ya akpalitela uche zuru ụwa ọnụ.Na Nọvemba 26, WHO akọwaala ụdị mutant a dị ka “iche iche iche echiche” (VOC) nke ise nke aha ya bụ mutant Omicron (Omicron).Ka ọ dị ugbu a, ụdị Omicrom variant agbasala ngwa ngwa gaa na mba ma ọ bụ mpaghara 19 gburugburu ụwa, ma nwee ike ibute ọgba aghara siri ike na mgbochi na njikwa ọrịa zuru ụwa ọnụ.
WHO kwukwara na Omicron nwere nnukwu mgbanwe mgbanwe, ụfọdụ n'ime ha na-echegbu onwe ya.WHO kwukwara na a na-achọpụta ụdị mutant nke "Omicron" ngwa ngwa karịa ụdị mutant ndị ọzọ kpatara mmụba nke ọrịa n'oge gara aga, na-egosi na ụdị mutant kachasị ọhụrụ nwere ike ịba uru.Iji gbochie mgbasa nke mutant nke ọhụrụ coronavirus Omicron abụrụla ebumnuche ọhụrụ maka mgbochi ọrịa zuru ụwa ọnụ.
Map nkesa mmụgharị nke Omicron(1)na Delta(2), Stanford University Coronavirus na Drug Resistance Database
Na mgbakwunye na inwekwu mmụgharị na protein spike, ụdị mutant nke Omicron nwekwara ọtụtụ saịtị mmụgharị na protein N.Ebe ọ bụ na ebumnuche nke nchọpụta antigen ọhụrụ coronavirus bụ protein N, ngbanwe nke protein N nwere ike imetụta antigen ọhụrụ nke coronavirus.Izi ezi nke ngwa ule nwere mmetụta.
| Tebụl 1. Ntụle nke N protein evolushọn nke dị iche iche mutant
| |
| Usoro nje
| N protein evolushọn |
| Alfa (B.1.1.7) | R203K;G204R; (> 50%) S194L (5-50%) D3H;D63G;T205I;M234I(1-5%) |
| Beta (B.1.351) | T205I (> 50%) P13S;T3621(5-50%) Q9H;Q28R;A35T;E38V;Q418H (1-5%) |
| Gamma (p.1) | P80R;S202C;R203K;G204R (>50%) A211S; D402Y; S4131 (1-5%) |
| Delta (B.1.617.2) | D63G; R203M; G215C; D377Y (> 50%) Q9L (> 5-50%) G18V; R385K (1-5%)
|
| Omicron (B.1.1.529) | P13L;R203K;G204R E31/R32/S33 Del |
Tụnyere protein Alfa-N, protein Omicron-N nwere ọdịiche nke ọnọdụ amino acid iri.Iji nyochaa arụmọrụ nchọpụta nke Omicron-N protein site na covid-19 antibody raw material of Keygen gene, anyị kwadebere recombinant Omicron-N protein na nke mbụ, wee mee nkwado nkwado site na Keygen Gene na ọtụtụ ndị ahịa.Nsonaazụ gosiri na ihe na-emepe emepe ihe mgbochi okpueze ọhụrụ nwere otu nsonaazụ nchọpụta maka protein Omicron-N recombinant, protein Alpha-N na protein Delta-N.Ihe mgbochi okpueze nke mepere emepe nwere ike hụ na izi ezi nke ngwa nje virus antigen ọhụrụ maka ịchọpụta ụdị Omicron..
| Tebụl 2 Nsonaazụ nchọpụta Omicron recombinant N protein site neocorona antibody | ||||||
| Antibody Ejikọtara ọnụ | Alfa-Nprotein | Omicron-protein | ||||
| 4.0ng/ml | 2.0ng/ml | 1.0ng/ml | 4.0ng/ml | 2.0ng/ml | 1.0ng/ml | |
| Atụmatụ 1 | G5 | G4 | G2 | G5 | G4 | G2 |
| Atụmatụ 2 | G5 | G4 | G2 | G5 | G4 | G2 |
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Oge nzipu: Dec-14-2021
