IVD reagent ihe nrịbama obi

Cardiac Troponin I (cTnI) bụ ụdị subụdị nke ezinụlọ troponin nke a na-ejikarị dị ka akara maka mmebi myocardial.Cardiac troponin I bụ kpọmkwem maka anụ ahụ obi ma na-achọpụta na serum naanị ma ọ bụrụ na myocardial merụrụ ahụ.N'ihi na troponin nke obi obi bụ ihe na-emetụ n'ahụ na kpọmkwem ihe na-egosi mmebi obi (myocardium), ọkwa ọbara nwere ike iji nyere aka ịmata ọdịiche dị n'etiti angina na-adịghị akwụ ụgwọ na myocardial infarction (mgbu obi) na ndị nwere obi mgbu ma ọ bụ nnukwu ọrịa obi.

A na-eji isoform nke obi obi nke TnT eme ihe dị ka ihe nrịbama nke mmerụ ahụ cell myocardial, dịka cTnI bụ.cTnT nwere otu ntọhapụ kinetics n'ime ọbara na otu uche maka obere mmerụ ahụ myocardial dị ka cTnI.N'ime ọbara ndị ọrịa myocardial infarction (AMI), a na-ahụkarị cTnT n'ụdị efu ebe a na-ahụkarị cTnI na mgbagwoju anya na TnC.

Troponin C, nke a makwaara dị ka TN-C ma ọ bụ TnC, bụ protein nke na-ebi na troponin complex na actin thin filaments nke akwara striated (obi, ngwa ngwa-twitch skeletal, ma ọ bụ ngwa ngwa-twitch skeletal) na ọ bụ maka ijikọta calcium iji rụọ ọrụ. mkpụkọ akwara.Edebere Troponin C site na mkpụrụ ndụ TNNC1 n'ime mmadụ maka ma akwara obi yana ngwa ngwa skeletal.

myoglobin bụ protein cytoplasmic nke na-ejikọta oxygen na otu heme.Ọ nwere naanị otu globulin, ebe hemoglobin nwere anọ.N'agbanyeghị na otu heme ya dị na Hb, Mb nwere mmekọrịta dị elu maka oxygen karịa hemoglobin.Ọdịiche a metụtara ọrụ ya dị iche iche: ebe hemoglobin na-ebuga oxygen, ọrụ myoglobin bụ ịchekwa oxygen.

A na-eji Digoxin agwọ ọrịa obi, na-ejikarị ọgwụ ndị ọzọ.A na-ejikwa ya agwọ ụfọdụ ụdị nkụchi obi na-adịghị mma (dị ka fibrillation na-adịghị ala ala).Ịgwọ nkụchi obi nwere ike inye aka ịnọgide na-enwe ike ịga ije na mgbatị ahụ ma nwee ike imeziwanye ike nke obi gị.Ịgwọ nkụchi obi na-adịghị ahụkebe nwekwara ike imeziwanye ikike imega ahụ gị. Digoxin bụ nke otu ọgwụ a na-akpọ glycosides obi.Ọ na-arụ ọrụ site na-emetụta ụfọdụ mineral (sodium na potassium) n'ime mkpụrụ ndụ obi.Nke a na-ebelata nrụgide na obi ma na-enyere ya aka ịnọgide na-enwe nkụja obi kwesịrị ekwesị, kwụ ọtọ na nke siri ike.

CK-MB na nnukwu myocardial infarction (AMI), na CK-BB na mmebi ụbụrụ na ụbụrụ ọjọọ nke tract intestinal.A na-atụle CK-MB ma ọ bụ site na ọrụ enzyme ma ọ bụ ntinye uche dị ukwuu ma tụọ ya dị ka ihe nrịbama ọ bụghị nanị na nchọpụta nke AMI kamakwa na AMI a na-enyo enyo na angina na-adịghị akwụ ụgwọ.

Ụdị obi-Fatty-Acid-Binding-Protein (hFABP) bụ protein, nke na-etinye aka na njem myocardial intracellular (Bruins Slot et al., 2010; Reiter et al., 2013).Mgbe necrosis myocardial necrosis hFABP na-ahapụ ngwa ngwa n'ime ọbara ma ya mere a nyochara ya dị ka biomarker maka AMI.Agbanyeghị, n'ihi mmetụta dị ala na nkọwapụta hFABP egosighi na ọ bara uru, ma e jiri ya tụnyere arụmọrụ nchọpụta nke hs-Tn assays (Bruins Slot et al., 2010; Reiter et al., 2013).

Lipoprotein Associated Phospholipase A2(Lp-PLA2)

Lipids bụ abụba dị n'ọbara gị.Lipoproteins bụ ngwakọta nke abụba na protein ndị na-ebu abụba dị n'ọbara gị.Ọ bụrụ na ị nwere Lp-PLA2 n'ọbara gị, ị nwere ike ịnwe oke abụba n'ime akwara gị nke nwere ihe ize ndụ nke ịgbawa na ịkpata ọrịa obi ma ọ bụ ọrịa strok.

D-dimer (ma ọ bụ D dimer) bụ ngwaahịa na-emebi fibrin (ma ọ bụ FDP), obere iberibe protein dị n'ime ọbara mgbe fibrinolysis mebiri emebi ọbara.Akpọrọ ya aha n'ihi na o nwere iberibe abụọ D nke protein fibrin jikọtara ya na njikọ cross-link.